SOME CYCLIZATION REACTIONS WITH 4-THIOHYDANTOIN: SYNTHESIS OF SOME NOVEL THIOPYRANOIMIDAZOLES, THIENOIMIDAZOLES AND IMIDAZOQUINOLINES AND SOME METAL COMPLEXES WITH BIOLOGICAL INTEREST

Abstract

Abstract 4-Thiohydantoin (II) with chloroacetic acid, chloroacetanilides and cyanothioformamides gave thieno[2,3-d)imidazoles (IV, V and IX), respectively. α,β-Unsaturated nitriles and anthranilic acids reacted with (II) to produce thiopyrano[2,3-d]imidazoles (III) and imidazo[4,5-b]quinolines (VII). Some metal complexes were prepared and the antimicrobial activity of some selected compounds was also reported.