Publication | Closed Access
Ultralow Voltage, OTFT‐Based Sensor for Label‐Free DNA Detection
127
Citations
19
References
2012
Year
EngineeringDna AnalysisMolecular BiologyBiomedical EngineeringDna ComputingMolecular DiagnosticsDna Hybridization DetectionOligonucleotideDna ReplicationBiomedical AnalysisUnprecedented SelectivityBiomolecular EngineeringBiomedical SensorsBiomedical DiagnosticsUltralow VoltageTransduction MechanismBioelectronicsNatural SciencesGenetic EngineeringSynthetic BiologyNucleic Acid AmplificationGenome Editing
An organic ultralow voltage field effect transistor for DNA hybridization detection is presented. The transduction mechanism is based on a field-effect modulation due to the electrical charge of the oligonucleotides, so label-free detection can be performed. The device shows a sub-nanometer detection limit and unprecedented selectivity with respect to single nucleotide polymorphism.
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