Mizoroki−Heck Arylation of α,β-Unsaturated Acids with a Hybrid Fluorous Ether, F-626:  Facile Filtrative Separation of Products and Efficient Recycling of a Reaction Medium Containing a Catalyst

Abstract

The Mizoroki-Heck reaction was carried out using a fluorous ether F-626 as the solvent and a fluorous Pd carbene complex as the catalyst. When carboxylic acids are the products, separation of both the F-626 and the Pd catalyst from the products can be conveniently carried out by simple filtration. The F-626 filtrates containing the Pd catalyst can be recycled.