A Chiral Pool Based Synthesis of Platensimycin

Abstract

Extensive pharming: An expedient entry into the tetracycle 2, a late-stage synthetic intermediate en route to the broad-spectrum antibiotic (−)-platensimycin (1) has been accomplished. The strategy involves a series of cyclizations starting from the inexpensive chiral pool starting material (R)-(−)-carvone. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2008/z705080_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.