Insulin Sensitivity in Multiple Pathways Is Differently Affected During Zidovudine/Lamivudine-Containing Compared With NRTI-Sparing Combination Antiretroviral Therapy - Concepedia

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Insulin Sensitivity in Multiple Pathways Is Differently Affected During Zidovudine/Lamivudine-Containing Compared With NRTI-Sparing Combination Antiretroviral Therapy

25

Citations

25

References

2010

Year

Marit G. A. van Vonderen, Regje M. E. Blümer, Elly A. Hassink, Jussi Sutinen, Mariëtte T. Ackermans, Michiel A. van Agtmael, Hannele Yki‐Järvinen, Sven A. Danner, Mireille J. Serlie, Hans P. Sauerwein,

JAIDS Journal of Acquired Immune Deficiency Syndromes

Abstract

Treatment with ZDV/3TC/LPV/r versus NVP/LPV/r differentially affects glucose and lipid metabolism. The ZDV/3TC/LPV/r regimen induced peripheral insulin resistance, a transient increase in basal lipolysis and a transient decrease in insulin-mediated inhibition of lipolysis, whereas hepatic insulin sensitivity improved with the NVP/LPV/r regimen.

References

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