Angewandte Chemie International Edition · 2011 · 267 citations · 38 references
Natural SciencesBiochemistryChemistryCatalysisInorganic ChemistryOrganic ChemistryHeterocycle SynthesisHeterocyclic ChemistryOrganic SynthesisAsymmetric Heterocycle SynthesisEnantioselective SynthesisHeterocyclic Reactivity
Tough nut to crack: Chiral bidentate N-heterocyclic carbene copper complexes were designed that promote enantioselective hydroborations of one of the most difficult substrate classes: acyclic and exocyclic 1,1-disubstituted alkenes undergo reaction with >98 % site selectivity, in up to >98 % yield and e.r=96.5:3.5 (see scheme, B2(pin)2 = bis(pinacolato)diboron).
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Catalytic Z-selective olefin cross-metathesis for natural product synthesis
Simon J. Meek, Robert V. O’Brien, Josep Llaveria et al. · Nature · 2011 · 401 citations
Joshua J. Van Veldhuizen, John E. Campbell, Russell E. Giudici et al. · Journal of the American Chemical Society · 2005 · 363 citations