Synthesis of Chiral Aliphatic Amines through Asymmetric Hydrogenation

Abstract

The direct route: A Rhodium-catalyzed asymmetric hydrogenation method for the efficient synthesis of a broad range of chiral allylic amines and aliphatic amines from readily available materials was developed. A chiral Z-allylic amine was obtained for the first time through a Rhodium–DuanPhos-catalyzed asymmetric hydrogenation. TMS=Trimethylsilyl, cod=cyclooctadiene, TON=turnover number. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.