Bupropion-SR, Sertraline, or Venlafaxine-XR after Failure of SSRIs for Depression

Abstract

After unsuccessful treatment with an SSRI, approximately one in four patients had a remission of symptoms after switching to another antidepressant. Any one of the medications in the study provided a reasonable second-step choice for patients with depression. (ClinicalTrials.gov number, NCT00021528.).