Angewandte Chemie International Edition · 2006 · 229 citations · 43 references
Natural SciencesChemistryCatalysisInorganic ChemistryOrganic ChemistryChemical ReactionsCoordination ChemistryHeterocycle SynthesisHeterocyclic ChemistryReaction Mechanisms[4+2] CycloadditionAlkyne Cycloaddition ReactionsCatalyst Structure - Activity RelationshipsEnyne CyclizationMetal-mediated Cyclization
Going for gold: AuI-catalyzed cyclizations of functionalized enynes lead to the ready assembly of tricyclic carbon skeletons that are present in a number of naturally occurring compounds. An alkenyl gold intermediate is formed in the cyclization of the enynes and can be trapped in 5-exo-dig or 6-endo-dig Prins reactions to form an additional CC bond. Z=C(CO2Me)2, NTs; R=H, Me, iPr.
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Cristina Nieto‐Oberhuber, Salomé López, Antonio M. Echavarren · Journal of the American Chemical Society · 2005 · 561 citations