Journal of General Virology · 1995 · 178 citations · 0 references
Life SciencesCell BiologyInfectious DiseasesApoptosisMolecular VirologyVirologyDna Damage-induced ApoptosisApoptosis In Lymphoid OrgansApoptosis In Viral InfectionApoptosis Of Lymphoid CellsApoptosis-related Dna DamageApoptotic MorphologyRespiratory Viral PathologyViral Induced Apoptosis
Intranasal exposure of mice to influenza virus led to cell death in bronchial/bronchiolar epithelial cells, alveolar cells and lymphoid cells. These cells displayed fragmentation of nuclei and chromatin condensation. Nick end-labelling of DNA in situ confirmed that such apoptotic cells had fragmented DNA. These results suggest that the influenza virus induces apoptosis in vivo.