Journal of Pharmacy and Pharmacology · 1963 · 41 citations · 8 references
PharmacyBiochemistryPharmacokineticsHepatic PharmacokineticsPharmaceutical ToxicologyRadioisotope HandlingBile Acid MetabolismBile SecretionBiliary ExcretionBiliary Excretion Of MetabolitesGastrointestinal PharmacologyBiliary Excretion KineticsBiliary Metabolite Profiling
Abstract Tritium-labelled β-glycyrrhetic acid was prepared and administered orally, subdermally and intraperitoneally to male and female rats. Most of the radioactivity was excreted in the faeces, only traces being found in the urine. Administered to rats with biliary cannulae most of the radioactivity was excreted in the bile. Three metabolites of β-glycyrrhetic acid have been detected in the bile, but these have not yet been identified.
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A cage which limits the activity of rats.
Jesse L. Bollman · PubMed · 1948 · 273 citations
CLINICAL TRIAL OF A TRITERPENOID LIQUORICE COMPOUND IN GASTRIC AND DUODENAL ULCER
Richard Doll, Ivor D. Hill, C. Frederick Hutton et al. · The Lancet · 1962 · 215 citations