Investigation of non‐covalent interaction of natural flexible cyclic molecules with telomeric RNA G‐quadruplexes by electrospray ionization mass spectrometry

Abstract

Three flexible cyclic small molecules were found to be potential telomeric RNA G-quadruplex ligands, especially cepharanthine, which has high affinity and binds most tightly to the RNA G-quadruplexes. These findings may provide further implications in the regulation of telomeric RNA and telomerase activity.