Journal of Clinical Investigation · 1960 · 169 citations · 25 references
MedicineNephrologyPhysiologyMineral MetabolismRenal PathophysiologyWater Balance StudiesElectrolyte HomeostasisFluid HomeostasisRenal PhysiologySodium BalanceSodium HomeostasisTubular ReabsorptionAntidiuretic Hormone PhysiologyDiuretic MechanismsProximal Tubular DysfunctionProximal Tubular TransportRenal Water ReabsorptionRenal Water RetentionSodium Balance RegulationTubular Sodium Reabsorption
It is well established that certain patients with hepatic cirrhosis show impaired water diuresis fol- lowing water loads (1). With this limitation in free water excretion, hyponatremia may develop on average water intakes. It has been asserted and denied that antidiuretic hormone (ADH), secreted in excess or inadequately inactivated, is responsi- ble for the water retention (2, 3). In this study the role of antidiuretic hormone in cirrhosis is re- examined. The results do not support the concept that it plays the primary role in the retention of water.
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