Genomic Variation of Human Papillomavirus Type 16 and Risk for High Grade Cervical Intraepithelial Neoplasia

Abstract

This study suggests that the risk of developing CIN 2-3 is not the same with all variants of HPV16 and that nonprototype-like variants confer a greater risk compared with prototype-like variants. The important genomic differences underlying this increased risk of CIN 2-3 remain to be determined.