Concepedia

Modulation of protease-activated receptor expression by Porphyromonas gingivalis in human gingival epithelial cells

Diya Zhang, Shenglai Li, Lingjing Hu, Lieping Sheng, Lili Chen

BMC Oral Health · 2015 · 12 citations · 36 references

DOIFull text

Open access

Abstract

Our study shows that PAR-1, PAR-2 and PAR-3 are expressed in GECs. P. gingivalis proteases play a role in the regulation of innate immune responses in GECs. GECs use PARs to recognize P. gingivalis and mediate cell responses involved in innate immunity.

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