Peripheral Effects of Morphine and Expression of μ-Opioid Receptors in the Dorsal Root Ganglia during Neuropathic Pain: Nitric Oxide Signaling

Abstract

These results suggest that the peripheral nitric oxide-cGMP-PKG-KATP signaling pathway activation participates in the local antiallodynic effects of morphine after sciatic nerve injury and that nitric oxide, synthesized by NOS1 and NOS2, is implicated in the dorsal root ganglia down-regulation of MOR during neuropathic pain.