Glycerol-3-Phosphate Acyltransferase 1 Deficiency in <i>ob/ob</i> Mice Diminishes Hepatic Steatosis but Does Not Protect Against Insulin Resistance or Obesity

Abstract

These results suggest that decreasing hepatic steatosis alone does not improve insulin resistance, and that factors other than increased hepatic DAG and TAG contribute to hepatic insulin resistance in this genetically obese model. They also show that the SREBP1-mediated induction of hepatic steatosis in ob/ob mice requires Gpat1.