Concepedia

Publication | Closed Access

Potential Mechanisms for Thrombocytopenia Development with Trastuzumab Emtansine (T-DM1)

DOI

199

Citations

27

References

2014

Year

Hirdesh Uppal, Estelle Doudement, Kaushiki Mahapatra, Walter C. Darbonne, Daniela Bumbaca, Ben‐Quan Shen, Xiaoyan Du, Ola M. Saad, Kristin Harden Bowles, Steve Olsen,
Clinical Cancer Research

Abstract

These data support the hypothesis that T-DM1-induced thrombocytopenia is mediated in large part by DM1-induced impairment of MK differentiation, with a less pronounced effect on mature MKs.

References

YearCitations

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