The Effect of Rifampin on Toxoplasma gondii

Abstract

Rifampin, at concentrations of 50 μg/ml and greater, significantly inhibited multiplication of toxoplasma in L-cell cultures. Similar concentrations also inhibited growth of L-cells. No effect of rifampin was found on toxoplasma RNA synthesis in toxoplasma preparations free of mammalian cells or on RNA synthesis in L-cells. Mice which had received rifampin in high doses by the oral or intraperitoneal routes were not protected against lethal infection with toxoplasma.