A facile approach for the synthesis of 3,4-dihydropyrimidin-2-(1H)-ones using a microwave promoted Biginelli protocol in ionic liquid

100 years of the biginelli dihydropyrimidine synthesis

C. Oliver Kappe · Tetrahedron · 1993 · 1.2K citations

Natural Sciences, Chemistry, Medicinal Chemistry +8

Dihydropyrimidine calcium channel blockers. 3. 3-Carbamoyl-4-aryl-1,2,3,4-tetrahydro-6-methyl-5-pyrimidinecarboxylic acid esters as orally effective antihypertensive agents

Karnail S. Atwal, Brian N. Swanson, Steven E. Unger et al. · Journal of Medicinal Chemistry · 1991 · 784 citations

Pharmacy, Medicinal Chemistry, Pharmacology +12

Calcium Entry Blockers and Activators: Conformational and Structural Determinants of Dihydropyrimidine Calcium Channel Modulators

George C. Rovnyak, S. David Kimball, Barbara Beyer et al. · Journal of Medicinal Chemistry · 1995 · 549 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17

Lanthanide Triflate Catalyzed Biginelli Reaction. One-Pot Synthesis of Dihydropyrimidinones under Solvent-Free Conditions

Yun Ma, Changtao Qian, Limin Wang et al. · The Journal of Organic Chemistry · 2000 · 518 citations

Natural Sciences, Chemistry, Catalysis +5

Unprecedented Catalytic Three Component One-Pot Condensation Reaction:  An Efficient Synthesis of 5-Alkoxycarbonyl- 4-aryl-3,4-dihydropyrimidin-2(1H)-ones

Essa Hu, Daniel R. Sidler, Ulf‐H. Dolling · The Journal of Organic Chemistry · 1998 · 501 citations

Natural Sciences, Chemistry, Catalysis +6