Specific Capture and Release of Circulating Tumor Cells Using Aptamer‐Modified Nanosubstrates

Abstract

A platform for capture and release of circulating tumor cells (CTCs) is demonstrated by utilizing aptamer grafted silicon nanowires. Here, single-stranded DNA-aptamers are generated via the Cell-SELEX process to serve as capture agents, allowing specific capture and release of non-small cell lung cancer (NSCLC) CTCs from whole-blood samples with minimum contamination and negligible disruption to CTC viability and functions.