Dynamics of cohesin proteins REC8, STAG3, SMC1 and SMC3 are consistent with a role in sister chromatid cohesion during meiosis in human oocytes

Abstract

The dynamics of cohesins REC8, STAG3, SMC1 beta and SMC3 suggest their participation in sister chromatid cohesion throughout the whole meiotic process in human oocytes. Our data do not support the view that decreased levels of SMC1 beta gene expression in older women are involved in age-related non-disjunction.