Hospitalization and Death Associated With Potentially Inappropriate Medication Prescriptions Among Elderly Nursing Home Residents

TLDR

The study investigates whether potentially inappropriate medication prescribing (PIRx) is linked to increased hospitalization and death among elderly long‑stay nursing home residents. Using the combined Beers criteria, the authors analyzed 3,372 residents aged 65+ from the 1996 Medical Expenditure Panel Survey Nursing Home Component and applied multivariate logistic regression with generalized estimating equations. Residents receiving PIRx had higher odds of hospitalization (OR 1.27) and death (OR 1.28), and intermittent or consecutive exposures further increased risks, with hospitalization OR 1.27–1.80 and death OR 1.89.

Abstract

<h3>Background</h3> This study examines the association of potentially inappropriate medication prescribing (PIRx) with hospitalization and death among elderly long-stay nursing home residents. <h3>Methods</h3> We defined PIRx using the combined version of the Beers criteria. Data were from the 1996 Medical Expenditure Panel Survey Nursing Home Component. The study sample included 3372 residents, 65 years and older, who had nursing home stays of 3 consecutive months or longer in 1996. We performed multivariate logistic regression analyses of longitudinal data using generalized estimating equations. <h3>Results</h3> Residents who received any PIRx had greater odds (odds ratio [OR], 1.27;<i>P</i> = .002) of being hospitalized in the following month than those receiving no PIRx. Residents with PIRx exposure for 2 consecutive months were at increased risk (OR, 1.27;<i>P</i> = .004) of hospitalization, as were those receiving PIRx in the second month only (OR, 1.80;<i>P</i> = .001), compared with those receiving no PIRx. Residents who received PIRx were at greater risk of death (OR, 1.28;<i>P</i> = .01) that month or the next. Residents with intermittent PIRx exposures were at greater odds of death (OR, 1.89;<i>P</i>&lt;.001), compared with those with no PIRx exposure. <h3>Conclusions</h3> The association of PIRx with subsequent adverse outcomes (hospitalization and death) provides new evidence of the importance of improving prescribing practices in the nursing home setting.