<scp>L</scp>‐<i>t</i>‐Leucine‐Catalyzed Direct Asymmetric Aldol Reaction of Cyclic Ketones

Abstract

Abstract L ‐ t ‐Leucine‐catalyzed direct asymmetric aldol reactions are described. In the aldol reaction of p ‐nitrobenzaldehyde with a cyclic ketone at room temperature, L ‐ t ‐leucine exhibits catalytic activity resulting in moderate to high diastereo‐ and enantioselectivity. Use of cycloheptanone or cyclooctanone as a substrate resulted in production of the syn selective product.