Concepedia

Prognostic Significance of <i>NPM1</i> Mutations in the Absence of <i>FLT3</i> –Internal Tandem Duplication in Older Patients With Acute Myeloid Leukemia: A SWOG and UK National Cancer Research Institute/Medical Research Council Report

Fabiana Ostronoff, Megan Othus, Michelle Lazenby, Elihu H. Estey, Frederick R. Appelbaum, Anna Evans, John E. Godwin, Amanda Gilkes, Kenneth J. Kopecky, Alan K. Burnett,

Journal of Clinical Oncology · 2015 · 131 citations · 29 references

DOIFull text

Open access

Abstract

NPM1-positive/FLT3-ITD-negative genotype remains a relatively favorable prognostic factor for patients with AML age 55 to 65 years but not in those age > 65 years.

References

29

Cytoplasmic Nucleophosmin in Acute Myelogenous Leukemia with a Normal Karyotype

Brunangelo Falini, Cristina Mecucci, Enrico Tiacci et al. · New England Journal of Medicine · 2005 · 1.9K citations · Full text

Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: association with FAB subtypes and identification of subgroups with poor prognosis

Christian Thiede, Christine Steudel, Brigitte Mohr et al. · Blood · 2002 · 1.7K citations · Full text

Mutations and Treatment Outcome in Cytogenetically Normal Acute Myeloid Leukemia

Richard F. Schlenk, Konstanze Döhner, Jürgen Krauter et al. · New England Journal of Medicine · 2008 · 1.6K citations

The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: analysis of 854 patients from the United Kingdom Medical Research Council AML 10 and 12 trials

Panagiotis Kottaridis, Rosemary E. Gale, Marion E. Frew et al. · Blood · 2001 · 1.5K citations · Full text

Age and acute myeloid leukemia

Frederick R. Appelbaum, Holly Gundacker, David R. Head et al. · Blood · 2006 · 1.3K citations · Full text