Helvetica Chimica Acta · 2000 · 45 citations · 0 references
Medicinal ChemistryScorzonera HumilisBioorganic ChemistryBiochemistryNatural SciencesMedicineTyrolean OriginSecondary MetaboliteHeterocycle ChemistryNatural CompoundsPhytochemistryPharmacologyDerivative (Chemistry)Primary MetaboliteDrug DiscoveryNatural Product Synthesis
Tyrolobibenzyls A (2), B (3), and C (4) were isolated from Scorzonera humilis (Asteraceae) of Tyrolean origin. Compounds 2 and 3 possess a unique phenylethyl-benzofuran backbone and represent a new class of natural compounds. Structural assignments are based on 1D and 2D NMR as well as MS data. Furthermore, peracetylated derivatives of compounds 3 and 4 were synthesized. Pharmacological evaluation of these compounds by the [3H]thymidine assay showed no pronounced cytotoxicity.