Advancing Drug Innovation for Neglected Diseases—Criteria for Lead Progression

Solomon Nwaka, Bernadette Ramirez, Reto Brun, +3

PLoS neglected tropical diseases

Drug TargetPharmaceutical InnovationDrug ResistanceTranslational MedicineMedicinal Chemistry +14

The CD of ligand‐DNA systems. 2. Poly(dA‐dT) B‐DNA

Reidar Lyng, Alison Rodger, Bengt Nordén

Biopolymers

Synthesis and Antiprotozoal Activity of Aza-Analogues of Furamidine

Mohamed A. Ismail, Reto Brun, Judy D. Easterbrook, +3

Journal of Medicinal Chemistry

New Treatment Option for Second-Stage African Sleeping Sickness: In Vitro and In Vivo Efficacy of Aza Analogs of DB289

Tanja Wenzler, David W. Boykin, Mohamed A. Ismail, +3

Antimicrobial Agents and Chemotherapy

Antiparasitic AgentVivo EfficacyPharmacotherapyDrug ResistanceMedicinal Chemistry +16

Diamidines as antitrypanosomal, antileishmanial and antimalarial agents.

Karl A. Werbovetz

PubMed

Antimalarial AgentsAntiparasitic AgentMalariaPharmacotherapyVisceral Leishmaniasis +15

New Bis(2-aminoimidazoline) and Bisguanidine DNA Minor Groove Binders with Potent in Vivo Antitrypanosomal and Antiplasmodial Activity

Fernando Rodrı́guez, Isabel Rozas, Marcel Kaiser, +5

Journal of Medicinal Chemistry

Anti-pneumocystis activity of bis-amidoximes and bis-o-alkylamidoximes prodrugs

David W. Boykin, Arvind Kumar, James Edwin Hall, +2

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryPharmaceutical ScienceBiochemistryNatural SciencesMedicine +5

4‐Picoline‐2,2′:6′,2″‐terpyridine‐platinum(II) — A potent intercalator of DNA

A McCoubrey, Harriet C. Latham, Peter R. Cook, +2

FEBS Letters

Efficacy of the diamidine DB75 and its prodrug DB289, against murine models of human African trypanosomiasis

John K. Thuita, Simon Karanja, Tanja Wenzler, +5

Acta Tropica

Translational MedicineAntiparasitic AgentMedicineParasitic ProtozoaMalaria +8

Thiophene-Based Diamidine Forms a “Super” AT Binding Minor Groove Agent

Sirish Mallena, Michael P. H. Lee, Christian Bailly, +4

Journal of the American Chemical Society