Angewandte Chemie International Edition · 2012 · 85 citations · 10 references
Synaptic TransmissionNeurotransmitterPharmacotherapyNeurotransmissionOptogeneticsSynaptic SignalingNeurochemistryHealth SciencesMolecular PhysiologyPhotochemistryReceptor (Biochemistry)Ion ChannelsNeuropharmacologyLight SwitchPharmacologyPhotochromismAmpa ReceptorsInhibitory NeurotransmittersSynaptic PlasticitySignal TransductionNeurophysiologyCellular NeuroscienceFunctional SelectivityPhysiologyMammalian BrainNeuroscienceMedicine
Light switch: A photochromic agonist ATA-3 (see scheme) of AMPA receptors, arguably the most important class of ionotropic glutamate receptors, is shown to be subtype selective, activates the AMPA receptor GluA2 in the dark, and is quickly turned off when irradiated with blue–green light. It can be used to effectively control neuronal activity in the mammalian brain.
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