Concepedia

Addition of Either Lonidamine or Granulocyte Colony-Stimulating Factor Does Not Improve Survival in Early Breast Cancer Patients Treated With High-Dose Epirubicin and Cyclophosphamide

Paola Papaldo, Massimo Lopez, Enrico Cortesi, Eugenio Cammilluzzi, Mauro Antimi, E. Terzoli, Giuseppe Lepidini, Patrizia Vici, Carlo Barone, G. Ferretti,

Journal of Clinical Oncology · 2003 · 74 citations · 30 references

DOI

Abstract

EC is active and well tolerated in patients with early breast cancer. The addition of LND or G-CSF does not improve DFS or OS.

References

30

Two months of doxorubicin-cyclophosphamide with and without interval reinduction therapy compared with 6 months of cyclophosphamide, methotrexate, and fluorouracil in positive-node breast cancer patients with tamoxifen-nonresponsive tumors: results from the National Surgical Adjuvant Breast and Bowel Project B-15.

Bernard Fisher, Ann Brown, N V Dimitrov et al. · Journal of Clinical Oncology · 1990 · 627 citations

, , +15

Randomized trial of intensive cyclophosphamide, epirubicin, and fluorouracil chemotherapy compared with cyclophosphamide, methotrexate, and fluorouracil in premenopausal women with node-positive breast cancer. National Cancer Institute of Canada Clinical Trials Group.

Mark N. Levine, V. Bramwell, Kathleen I. Pritchard et al. · Journal of Clinical Oncology · 1998 · 622 citations

Benefit of a High-Dose Epirubicin Regimen in Adjuvant Chemotherapy for Node-Positive Breast Cancer Patients With Poor Prognostic Factors: 5-Year Follow-Up Results of French Adjuvant Study Group 05 Randomized Trial

Journal of Clinical Oncology · 2001 · 253 citations

Sequential methotrexate and fluorouracil for the treatment of node-negative breast cancer patients with estrogen receptor-negative tumors: eight-year results from National Surgical Adjuvant Breast and Bowel Project (NSABP) B-13 and first report of findings from NSABP B-19 comparing methotrexate and fluorouracil with conventional cyclophosphamide, methotrexate, and fluorouracil.

Bernard Fisher, James J. Dignam, Eleftherios P. Mamounas et al. · Journal of Clinical Oncology · 1996 · 234 citations

Lonidamine triggers apoptosis via a direct, Bcl-2-inhibited effect on the mitochondrial permeability transition pore

L Ravagnan, Isabel Marzo, Paola Costantini et al. · Oncogene · 1999 · 211 citations

, , +11