Sex-Dependent Regulation of Fibrosis and Inflammation in Human Left Ventricular Remodelling Under Pressure Overload

Abstract

We conclude that in pressure overload distinct molecular processes are regulated between men and women. Maladaptive LV remodelling occurs more frequently in men and is associated with greater activation of profibrotic and inflammatory markers. Collectively, sex-specific regulation of these processes may contribute to sex differences in the progression to heart failure.