Catalytic Asymmetric Intramolecular Hydroacylation with Rhodium/Phosphoramidite–Alkene Ligand Complexes

Abstract

Give me a P: An asymmetric intramolecular Rh-catalyzed hydroacylation reaction of pent-4-enals for the preparation of functionalized cyclopentanones in good yield and high enantioselectivity is described (see scheme, DCE=dichloroethane). This process uses rhodium complexes featuring novel modular phosphoramidite–alkene ligands and achiral phosphine coligands. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.