Concepedia

Vascular endothelial dysfunction and superoxide anion production in heart failure are p38 MAP kinase-dependent

Joachim Widder, Th. Behr, Daniela Fraccarollo, Konghe Hu, Paolo Galuppo, Piet W.L. Tas, Christiane E. Angermann, G. Ertl, Johann Bauersachs

Cardiovascular Research · 2004 · 46 citations · 22 references

DOIFull text

Open access

Abstract

Vascular p38 MAP kinase is markedly activated in rats with CHF. Chronic p38 MAP kinase inhibition with SB239063 prevented endothelial vasomotor dysfunction through reduction of superoxide anion production.

References

22

Mechanisms Underlying Endothelial Dysfunction in Diabetes Mellitus

Ulrich Hink, Huige Li, Hanke Mollnau et al. · Circulation Research · 2001 · 1.2K citations

Endothelium-dependent vasodilation is attenuated in patients with heart failure.

S H Kubo, Thomas S. Rector, Alan J. Bank et al. · Circulation · 1991 · 775 citations · Full text

p38 Mitogen-activated Protein Kinase Is a Critical Component of the Redox-sensitive Signaling Pathways Activated by Angiotensin II

Masuko Ushio‐Fukai, R. Wayne Alexander, Marjorie Akers et al. · Journal of Biological Chemistry · 1998 · 653 citations · Full text

Differential Activation of Signal Transduction Pathways in Human Hearts With Hypertrophy Versus Advanced Heart Failure

Syed Haq, Gabriel Choukroun, Hae Sook Lim et al. · Circulation · 2001 · 434 citations

Impaired endothelium-mediated vasodilation in the peripheral vasculature of patients with congestive heart failure

Stuart D. Katz, Luigi M. Biasucci, Carlo Sabbà et al. · Journal of the American College of Cardiology · 1992 · 391 citations

, , +10