Vascular endothelial dysfunction and superoxide anion production in heart failure are p38 MAP kinase-dependent - Concepedia

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Vascular endothelial dysfunction and superoxide anion production in heart failure are p38 MAP kinase-dependent

DOI Full Paper Access

46

Citations

22

References

2004

Year

Joachim Widder, Th. Behr, Daniela Fraccarollo, Konghe Hu, Paolo Galuppo, Piet W.L. Tas, Christiane E. Angermann, G. Ertl, Johann Bauersachs

Cardiovascular Research

Abstract

Vascular p38 MAP kinase is markedly activated in rats with CHF. Chronic p38 MAP kinase inhibition with SB239063 prevented endothelial vasomotor dysfunction through reduction of superoxide anion production.

References

	Year	Citations
Mechanisms Underlying Endothelial Dysfunction in Diabetes Mellitus Ulrich Hink, Huige Li, Hanke Mollnau, Circulation Research	2001	1.2K
Endothelium-dependent vasodilation is attenuated in patients with heart failure. S H Kubo, Thomas S. Rector, Alan J. Bank, Circulation	1991	775
p38 Mitogen-activated Protein Kinase Is a Critical Component of the Redox-sensitive Signaling Pathways Activated by Angiotensin II Masuko Ushio‐Fukai, R. Wayne Alexander, Marjorie Akers, Journal of Biological Chemistry	1998	653
Differential Activation of Signal Transduction Pathways in Human Hearts With Hypertrophy Versus Advanced Heart Failure Syed Haq, Gabriel Choukroun, Hae Sook Lim, Circulation	2001	434
Impaired endothelium-mediated vasodilation in the peripheral vasculature of patients with congestive heart failure Stuart D. Katz, Luigi M. Biasucci, Carlo Sabbà, Journal of the American College of Cardiology Heart FailureCardiovascular DiseasePhysiologyEndothelial DysfunctionVascular Biology	1992	391
The Interstitium of the Human Arterial Wall Contains Very Large Amounts of Extracellular Superoxide Dismutase Pontus Strålin, Kurt Karlsson, Bengt O. Johansson, Arteriosclerosis Thrombosis and Vascular Biology	1995	385
Endothelial Dysfunction in Chronic Myocardial Infarction Despite Increased Vascular Endothelial Nitric Oxide Synthase and Soluble Guanylate Cyclase Expression Johann Bauersachs, Anne Bouloumié, Daniela Fraccarollo, Circulation	1999	358
Improvement of Left Ventricular Remodeling and Function by Hydroxymethylglutaryl Coenzyme A Reductase Inhibition With Cerivastatin in Rats With Heart Failure After Myocardial Infarction Johann Bauersachs, Paolo Galuppo, Daniela Fraccarollo, Circulation	2001	263
Vascular Extracellular Superoxide Dismutase Activity in Patients With Coronary Artery Disease Ulf Landmesser, Roland Merten, Stephan Spiekermann, Circulation	2000	253
SB 239063, a Potent p38 MAP Kinase Inhibitor, Reduces Inflammatory Cytokine Production, Airways Eosinophil Infiltration, and Persistence David C. Underwood, Ruth R. Osborn, Charles J. Kotzer, Journal of Pharmacology and Experimental Therapeutics	2000	244

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