Concepedia

Bach1 Represses Wnt/β-Catenin Signaling and Angiogenesis

Jiang Li, Meng Yin, Xiangxiang Wei, Junxu Liu, Xinhong Wang, Cong Niu, Xueling Kang, Jie Xu, Zhongwei Zhou, Shaoyang Sun,

Circulation Research · 2015 · 137 citations · 35 references

DOIFull text

Open access

Abstract

Bach1 suppresses angiogenesis after ischemic injury and impairs Wnt/β-catenin signaling by disrupting the interaction between β-catenin and TCF4 and by recruiting histone deacetylase 1 to the promoter of TCF4-targeted genes.

References

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Bach Proteins Belong to a Novel Family of BTB-Basic Leucine Zipper Transcription Factors That Interact with MafK and Regulate Transcription through the NF-E2 Site

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