Concepedia

Hyperosmolar Sexual Lubricant Causes Epithelial Damage in the Distal Colon: Potential Implication for HIV Transmission

Edward J. Fuchs, Linda A. Lee, Michael Torbenson, Teresa L. Parsons, Rahul P. Bakshi, Anita M. Guidos, Richard L. Wahl, Craig W. Hendrix

The Journal of Infectious Diseases · 2007 · 146 citations · 29 references

DOI

Abstract

Rectally applied hyperosmolar gels induce greater epithelial denudation and luminal secretion than iso-osmolar gels. Because denudation plausibly increases the risk of HIV transmission, hyperosmolar gels make poor rectal microbicide formulations, and hyperosmolar sexual lubricants may increase susceptibility to HIV infection.

References

29

Effectiveness of COL-1492, a nonoxynol-9 vaginal gel, on HIV-1 transmission in female sex workers: a randomised controlled trial

Lut Van Damme, Gita Ramjee, Michel Alary et al. · The Lancet · 2002 · 795 citations

, , +10

FACTORS ASSOCIATED WITH PREVALENT HUMAN IMMUNODEFICIENCY VIRUS (HIV) INFECTION IN THE MULTICENTER AIDS COHORT STUDY

Joan S. Chmiel, Roger Detels, Richard A. Kaslow et al. · American Journal of Epidemiology · 1987 · 189 citations

Hepatitis B in Homosexual Men: Prevalence of Infection and Factors Related to Transmission

Marshall T. Schreeder, Suzanne Thompson, Stephen C. Hadler et al. · The Journal of Infectious Diseases · 1982 · 189 citations

, , +18

Association of Cervical Ectopy with Heterosexual Transmission of Human Immunodeficiency Virus: Results of a Study of Couples in Nairobi, Kenya

Gregory B. Moss, D.B.A. Clemetson, L J D'Costa et al. · The Journal of Infectious Diseases · 1991 · 186 citations

RISK FACTORS FOR AIDS AND HIV SEROPOSITIVITY IN HOMOSEXUAL MEN

Andrew R. Moss, Dennis Osmond, Peter Bacchetti et al. · American Journal of Epidemiology · 1987 · 182 citations