A Novel Dimeric Podophyllotoxin‐Type Lignan and a New Withanolide from <i>Withania coagulans</i>

Abstract

Abstract A novel dimeric lignan, bispicropodophyllin glucoside ( 1 ) and a highly oxygenated new withanolide, coagulin S ( 2 ) were isolated from the ethanolic extract of Withania coagulans. The structures were established on the basis of the spectroscopic data and have been identified as (5 S *,5a R *,8a R *,9 S *,15 S *,15a S *,18a S *,19 S *)‐9,19‐di‐ β ‐ D ‐glucopyranosyl‐5,8a,9,15,15a,18,18a,19‐octahydro‐5,15‐bis(3,4,5‐trimethoxyphenyl)bis([1,3]dioxolo[4′,5′:6,7]naphtho)[2,3‐ c: 2,3‐ h ][1,6]dioxecin‐6,16(5a H ,8 H )‐dione ( 1 ) and (20 S *,22 R *)‐5 α ,6 β ,14 α ,15 α ,17 β ,20,27‐heptahydroxy‐1‐oxowith‐24‐enolide ( 2 ), respectively.