Copper‐Catalyzed Rearrangement of Tertiary Amines through Oxidation of Aliphatic CH Bonds in Air or Oxygen: Direct Synthesis of α‐Amino Acetals

Abstract

A surprising turn of events: Mechanistic studies, including trapping, control, and isotope-labeling experiments, led to the proposal of a rearrangement mechanism involving oxidation of aliphatic CH bonds (see scheme; TMEDA=tetramethylethylenediamine).