Concepedia

Group A streptococci are protected from amoxicillin-mediated killing by vesicles containing  -lactamase derived from Haemophilus influenzae

Viveka Schaar, Ida Uddbäck, Tobias Nordström, Kristian Riesbeck

Journal of Antimicrobial Chemotherapy · 2013 · 65 citations · 13 references

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Abstract

This is the first report of the presence of β-lactamase in NTHi OMVs. We suggest that OMV-derived β-lactamase from coinfecting pathogens such as NTHi and M. catarrhalis may contribute to the occasional treatment failures seen in GAS tonsillitis.

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<i>Moraxella catarrhalis</i> Outer Membrane Vesicles Carry β-Lactamase and Promote Survival of <i>Streptococcus pneumoniae</i> and <i>Haemophilus influenzae</i> by Inactivating Amoxicillin

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