Antimicrobial Agents and Chemotherapy · 2007 · 13 citations · 20 references
Pathogenic MicrobiologyPathologyAntibiotic ResistanceBacterial PathogensDrug ResistanceGerman AdultsMacrolide Resistance GenotypesEmerging Infectious DiseaseInfection ControlAntimicrobial ResistanceHost-pathogen InteractionsHealth SciencesClonal SpreadClinical MicrobiologyAntimicrobial Resistance GeneAntimicrobial SusceptibilityMicrobial DiseaseAntibioticsEmerging Infectious DiseasesPathogenesisSerotype 14MicrobiologyMedicine
Isolates (3,845) obtained from German adults with invasive pneumococcal disease between 1992 and 2004 were investigated. Of these, 430 isolates (11.2%) were erythromycin A nonsusceptible. Macrolide resistance genotypes and multilocus sequence types were determined. Among the isolates, 35.6% were erm(B) positive and 63.5% were mef positive. Over the study period, the frequency of resistance rose significantly from 2.2 to 17.0% (P < 0.001). A serotype 14, sequence type 9 clone was the most widespread.
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Martin Maiden, Jane A. Bygraves, Edward J. Feil et al. · Proceedings of the National Academy of Sciences · 1998 · 3.8K citations
TREE-PUZZLE: maximum likelihood phylogenetic analysis using quartets and parallel computing
Heiko A. Schmidt, Korbinian Strimmer, Martin Vingron et al. · Bioinformatics · 2002 · 2.6K citations · Full text