Long-term Therapy for Herpes Retinitis in an Animal Model With High-Concentrated Liposome-Encapsulated HPMPC

Abstract

Reduced toxic effects and longer-term efficacy compared with free drug was observed. Given the 50 times higher activity of HPMPC against human cytomegalovirus than herpes simplex virus type 1, a single injection of 1000 micrograms of liposome-encapsulated HPMPC may have a very prolonged effect in the treatment of cytomegalovirus retinitis.