The Peutz-Jeghers Syndrome

Abstract

The Peutz-Jeghers syndrome is characterized by intestinal polyposis and mucocutaneous melanin pigmentation. It is inherited as a simple mendelian dominant, but sporadic cases may occur by gene mutation. Polyps are usually present from the gastroesophageal junction to the anus, and are hamartomas with little tendency to malignant degeneration. Recurrent abdominal pain from intussusception is the most frequent symptom, and chronic blood-loss anemia is often pres