Concepedia

Considering Usual Medical Care in Clinical Trial Design

Liza Dawson, Deborah A. Zarin, Ezekiel J. Emanuel, Lawrence M. Friedman, Bimal P. Chaudhari, Steven N. Goodman

PLoS Medicine · 2009 · 93 citations · 34 references

DOIFull text

Open access

Abstract

N Challenges often arise when researchers propose clinical trials incorporating usual care comparison groups.

References

34

Early Goal-Directed Therapy in the Treatment of Severe Sepsis and Septic Shock

Emanuel P. Rivers, Bryant Nguyen, Suzanne Havstad et al. · New England Journal of Medicine · 2001 · 10.7K citations · Full text

Comparison of Two Fluid-Management Strategies in Acute Lung Injury

New England Journal of Medicine · 2006 · 3.4K citations · Full text

A 14-Month Randomized Clinical Trial of Treatment Strategies for Attention-Deficit/Hyperactivity Disorder

Archives of General Psychiatry · 1999 · 3.4K citations

Cyclophosphamide and Cisplatin Compared with Paclitaxel and Cisplatin in Patients with Stage III and Stage IV Ovarian Cancer

William P. McGuire, William J. Hoskins, Mark F. Brady et al. · New England Journal of Medicine · 1996 · 2.9K citations · Full text

A Randomized Trial Comparing Lung-Volume–Reduction Surgery with Medical Therapy for Severe Emphysema

New England Journal of Medicine · 2003 · 2.1K citations · Full text