Concepedia

Mitochondrial Oxidative Stress in Aortic Stiffening With Age

Rui-Hai Zhou, Aleksandr E. Vendrov, Igor Tchivilev, Xi-Lin Niu, Kimberly Molnar, Mauricio Rojas, Jacqueline D. Carter, Haiyan Tong, George A. Stouffer, Nageswara R. Madamanchi,

Arteriosclerosis Thrombosis and Vascular Biology · 2011 · 114 citations · 52 references

DOIFull text

Open access

Abstract

Mitochondrial oxidative stress over a lifetime causes aortic stiffening, in part by inducing vascular wall remodeling, intrinsic changes in SMC stiffness, and aortic SMC apoptosis.

References

52

Aging: A Theory Based on Free Radical and Radiation Chemistry

Denham Harman · Journal of Gerontology · 1956 · 8.4K citations

, , +24

Relative expression software tool (REST(C)) for group-wise comparison and statistical analysis of relative expression results in real-time PCR

Michael W. Pfaffl · Nucleic Acids Research · 2002 · 7.3K citations · Full text

Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor

Anne Brunet, Azad Bonni, Michael J. Zigmond et al. · Cell · 1999 · 6.5K citations · Full text

, , +10

Arterial Stiffness and Cardiovascular Events

Gary F. Mitchell, Shih‐Jen Hwang, Ramachandran S. Vasan et al. · Circulation · 2010 · 2.2K citations

Endothelial Dysfunction, Oxidative Stress, and Risk of Cardiovascular Events in Patients With Coronary Artery Disease

Thomas Heitzer, Titus Schlinzig, Karoline Krohn et al. · Circulation · 2001 · 1.9K citations