Concepedia

Synthesis of Biphenyl-2-carbonitrile Derivatives via a Palladium-Catalyzed sp<sup>2</sup> C−H Bond Activation Using Cyano as a Directing Group

Wu Li, Zhipeng Xu, Peipei Sun, Xiaoqing Jiang, Min Fang

Organic Letters · 2011 · 92 citations · 24 references

DOI

Abstract

Pd(II)-catalyzed aromatic C-H bond activation using cyano as a directing group was carried out in TFA medium. Biphenyl-2-carbonitrile derivatives were therefore synthesized from aryl nitriles and aryl halides in moderate to good yields.

References

24

C-H Bond Functionalization in Complex Organic Synthesis

Kamil Godula, Dalibor Sameš · Science · 2006 · 2.1K citations

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Palladium- and Copper-Catalyzed Arylation of Carbon−Hydrogen Bonds

Olafs Daugulis, Hien‐Quang Do, Dmitry Shabashov · Accounts of Chemical Research · 2009 · 2K citations · Full text

Selective Intermolecular Carbon-Hydrogen Bond Activation by Synthetic Metal Complexes in Homogeneous Solution

Bruce A. Arndtsen, Robert G. Bergman, T. Andrew Mobley et al. · Accounts of Chemical Research · 1995 · 1.4K citations

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Catalytic Methods for CH Bond Functionalization: Application in Organic Synthesis

Fumitoshi Kakiuchi, Naoto Chatani · Advanced Synthesis & Catalysis · 2003 · 1.1K citations

The Catalytic Cross-Coupling of Unactivated Arenes

David R. Stuart, Keith Fagnou · Science · 2007 · 1K citations