Inhibition or Deletion of Soluble Epoxide Hydrolase Prevents Hyperglycemia, Promotes Insulin Secretion, and Reduces Islet Apoptosis

Protection from obesity-induced insulin resistance in mice lacking TNF-α function

K. Teoman Uysal, Sarah M. Wiesbrock, Michael W. Marino et al. · Nature · 1997 · 2.2K citations

Obesity, Metabolic Syndrome, Inflammation +14

Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1

John C. Yoon, Pere Puigserver, Guoxun Chen et al. · Nature · 2001 · 1.8K citations

Hepatic Gluconeogenesis, Transcriptional Regulation, Hepatology +7

Uncoupling Protein-2 Negatively Regulates Insulin Secretion and Is a Major Link between Obesity, β Cell Dysfunction, and Type 2 Diabetes

Chenyu Zhang, György Baffy, Pascale Perret et al. · Cell · 2001 · 912 citations · Full text

Obesity, Metabolic Syndrome, Insulin Resistance +14

Institute of Laboratory Animal Resources.

Thomas L. Wolfle · 1995 · 618 citations

Biology, Animal Testing, Animal Study +12

Evidence that glucose can control insulin release independently from its action on ATP-sensitive K+ channels in mouse B cells.

M Gembal, Patrick Gilon, Jean‐Claude Henquin · Journal of Clinical Investigation · 1992 · 496 citations · Full text

Mouse B Cells, Cellular Physiology, Insulin Signaling +24