Concepedia

Mesenteric injury after cardiopulmonary bypass: Role of poly(adenosine 5′-diphosphate-ribose) polymerase*

Gábor Szabó, Pál Soós, Susanne Mandera, Ulrike Heger, Christa Flechtenmacher, Leila Seres, Zsuzsanna K. Zsengellér, Falk-Udo Sack, Csaba Szabó, Siegfried Hagl

Critical Care Medicine · 2004 · 11 citations · 25 references

DOI

Abstract

PARP inhibition with INO-1001 improves the recovery of myocardial function and prevents mesenteric vascular dysfunction and tissue injury after cardiopulmonary bypass with hypothermic cardiac arrest.

References

25

DNA strand breakage, activation of poly (ADP-ribose) synthetase, and cellular energy depletion are involved in the cytotoxicity of macrophages and smooth muscle cells exposed to peroxynitrite.

Csaba Szabó, Basilia Zingarelli, Michael O′Connor et al. · Proceedings of the National Academy of Sciences · 1996 · 623 citations · Full text

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Endothelial dysfunction in a rat model of endotoxic shock. Importance of the activation of poly (ADP-ribose) synthetase by peroxynitrite.

Csaba Szabó, Salvatore Cuzzocrea, Basilia Zingarelli et al. · Journal of Clinical Investigation · 1997 · 358 citations · Full text

Beneficial effects of 3‐aminobenzamide, an inhibitor of poly (ADP‐ribose) synthetase in a rat model of splanchnic artery occlusion and reperfusion

Salvatore Cuzzocrea, Basilia Zingarelli, Giuseppina Costantino et al. · British Journal of Pharmacology · 1997 · 165 citations · Full text

, , +25

Poly(ADP-Ribose) Polymerase Inhibition Reduces Reperfusion Injury After Heart Transplantation

Gábor Szabó, Susanne Bährle, Nicole Stumpf et al. · Circulation Research · 2002 · 159 citations · Full text

Predictors of ARF after cardiac surgical procedures

Katherine R. Tuttle, Neil K. Worrall, Lynn R. Dahlstrom et al. · American Journal of Kidney Diseases · 2002 · 157 citations

, , +6