Concepedia

miR-21 down-regulation promotes apoptosis and inhibits invasion and migration abilities of OVCAR3 cells

Yanhui Lou, Zhumei Cui, Fuling Wang, Xingsheng Yang, Jinhua Qian

Clinical and investigative medicine · 2011 · 26 citations · 20 references

DOI

Abstract

Down-regulation of miR-21 dramatically increased apoptotic cell death and decreased cell proliferation, invasion and migration in OVCAR3 cells. MiR-21 may play an important role in the biological behaviors of epithelial ovarian carcinoma cells through negative control of the expression of PDCD4.

References

20

Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers

George A. Calin, Cinzia Sevignani, Calin Dan Dumitru et al. · Proceedings of the National Academy of Sciences · 2004 · 4.1K citations · Full text

MicroRNA-21 Regulates Expression of the PTEN Tumor Suppressor Gene in Human Hepatocellular Cancer

Fanyin Meng, Roger Henson, Hania Wehbe–Janek et al. · Gastroenterology · 2007 · 2.8K citations · Full text

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MicroRNA-21 Is an Antiapoptotic Factor in Human Glioblastoma Cells

Jennifer A. Chan, Anna M. Krichevsky, Kenneth S. Kosik · Cancer Research · 2005 · 2.5K citations

MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer

Irfan A. Asangani, Suhail Ahmed Kabeer Rasheed, Dessislava A. Nikolova et al. · Oncogene · 2007 · 1.9K citations

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miR-21-mediated tumor growth

M.-L. Si, Shengtao Zhu, Hui Wu et al. · Oncogene · 2006 · 1.6K citations

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