Concepedia

Risk of colorectal cancer in juvenile polyposis

L. A. A. Brosens, Arnout van Hattem, Linda M. Hylind, Christine A. Iacobuzio–Donahue, Katharine Romans, Jennifer E. Axilbund, Marcia Cruz–Correa, Anne C. Tersmette, G. J. A. Offerhaus, Francis M. Giardiello

Gut · 2007 · 271 citations · 13 references

DOIFull text

Open access

Abstract

Patients with JP have a markedly increased RR and absolute risk for colorectal cancer and require vigilant colorectal surveillance starting at young age. A low threshold for recommending surgery with consideration for removal of the entire colorectum seems warranted.

References

13

De Novo Crypt Formation and Juvenile Polyposis on BMP Inhibition in Mouse Intestine

Anna-Pavlina G. Haramis, Harry Begthel, Maaike van den Born et al. · Science · 2004 · 765 citations

, , +15

Juvenile polyposis–a precancerous condition

Jeremy R. Jass, Calvin B. Williams, H J R Bussey et al. · Histopathology · 1988 · 464 citations

The prevalence of <i>MADH4</i> and <i>BMPR1A</i> mutations in juvenile polyposis and absence of <i>BMPR2</i>, <i>BMPR1B</i>, and <i>ACVR1</i> mutations

James R. Howe · Journal of Medical Genetics · 2004 · 269 citations · Full text

Cohort Study Analysis with a FORTRAN Computer Program

Michel P. Coleman, A. DOUGLAS, C. HERMON et al. · International Journal of Epidemiology · 1986 · 255 citations

, , +12

Molecular Classification of Patients With Unexplained Hamartomatous and Hyperplastic Polyposis

Kevin Sweet · JAMA · 2005 · 233 citations