Photochemistry and Photobiology · 1973 · 45 citations · 8 references
Natural SciencesChemistryMolecular BiologyMicrobial GeneticsNucleic Acid BiochemistryNucleic Acid ChemistryBiological Effects Of RadiationDna ChemistryPhotochemical KineticsPhotochemistryRadiation ChemistryUltraviolet Radiation BiologyDna Damage InductionIon Effects On Nucleic AcidsPhotocleavage Of Nucleic AcidsRadiation Chemistry Of Biological MoleculesUltraviolet Light TreatmentUltraviolet PhotobiologyUltraviolet PhotochemistryUltraviolet-induced Dna Damage
Abstract— We have studied the influence of the heavy metal ions Ag + and Hg 2+ on the photoinactivation and photodimerization of transforming DNA and of bacteriophage. The rate of inactivation of Haemophilus influenzae transforming DNA by ultraviolet (UV) radiation was enhanced by a factor of 30 when it was complexed with Ag + . This enhancement was correlated with a comparable increase in the rate of thymine dimerization. In contrast, mercuric ions led to a reduction in the rates of both inactivation and dimerization. When we examined the effects of these metal ions on the photobiology of bacteriophage, we again found that Ag + enhanced and Hg 2+ reduced the rate of ultraviolet inactivation. These results demonstrate that heavy metals may be useful tools for studying the photochemistry and photobiology of nucleic acids.
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Studies on the Yeast Photoreactivating Enzyme
Amir Muhammed · Journal of Biological Chemistry · 1966 · 89 citations · Full text