Cardiorespiratory Fitness Attenuates the Effects of the Metabolic Syndrome on All-Cause and Cardiovascular Disease Mortality in Men

<h3>Background</h3> The metabolic syndrome is a prevalent condition that carries with it an increased risk of type 2 diabetes mellitus, cardiovascular disease (CVD), and mortality. <h3>Objective</h3> To determine the relationship between cardiorespiratory fitness (CRF) and mortality in healthy men and in those with the metabolic syndrome. <h3>Methods</h3> The sample included 19 223 men, aged 20 to 83 years, who received a clinical evaluation between 1979 and 1995 with mortality follow-up through December 31, 1996. There were 15 466 healthy men (80.5%) and 3757 men with the metabolic syndrome (19.5%). <h3>Results</h3> A total of 480 deaths (161 due to CVD) occurred during 196 298 man-years of follow-up. After adjustment for age, year of examination, smoking status, alcohol consumption, and parental CVD, the relative risks (RRs) (95% confidence interval) of all-cause and CVD mortality were 1.29 (1.05-1.57) and 1.89 (1.36-2.60), respectively, for men with the metabolic syndrome compared with healthy men. After the inclusion of CRF, the associations were not significant. The RRs comparing unfit with fit men for all-cause mortality were 2.18 (1.66-2.87) in healthy men and 2.01 (1.38-2.93) in men with the metabolic syndrome, whereas the RRs for CVD mortality for unfit vs fit men were 3.21 (2.03-5.07) in healthy men and 2.25 (1.27-3.97) in men with the metabolic syndrome. A significant dose-response relationship between CRF and mortality was also observed in men with the metabolic syndrome. <h3>Conclusion</h3> In this sample, CRF provided a strong protective effect against all-cause and CVD mortality in healthy men and men with the metabolic syndrome.