Matching and Mismatching Effects of Hybrid Chiral Biaxial Bisphosphine Ligands in Enantioselective Hydrogenation of Ketoesters

Abstract

Highly enantioselective hydrogenation reactions provide facile access to optically active α- and β-hydroxy acid derivatives (see scheme), which are very important chiral building blocks for the syntheses of a variety of natural products and biologically active molecules. The selectivity data revealed that the matched ligand system was L*, which afforded much higher enantioselectivities in hydrogenation of β-ketoesters and methyl benzoylformate. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.